Ahmad Darwish, senior research associate at Purdue University’s Elmore Family School of Electrical and Computer Engineering, prepares a microwave lyophilization experiment. A Purdue-led team has been awarded nearly $1 million to pursue a technology using microwaves to make the freeze-drying process twice as fast and more cost-effective. This could have a significant impact on the world’s vaccine supply chain. Like astronaut ice cream, many vaccines are made stable for transport and storage through freeze-drying, also known as lyophilization. (Purdue Research Foundation photo/Steve Martin)
WEST LAFAYETTE, Ind. – The COVID-19 pandemic put a spotlight on the vaccine supply chain and public health impact of vaccine stability. But Purdue University researchers have been working on the problem for years — using rocket science to advance a freeze-drying technology that lengthens product shelf life. And that technology could soon be available in the marketplace. Diy Freeze Dryer
A Purdue-led team has been awarded nearly $1 million to pursue a technology of using microwaves to make the freeze-drying process twice as fast and more cost-effective. Like astronaut ice cream, many vaccines are made stable for transport and storage through freeze-drying, also known as lyophilization.
“We want to push the technology further so that lifesaving treatments like COVID vaccines can easily reach every corner of the world,” said project leader Alina Alexeenko, senior associate dean for undergraduate education and academic programs at Purdue University in Indianapolis and professor of aeronautics and astronautics and chemical engineering in Purdue’s College of Engineering. “The conditions required for lyophilization are like those in outer space — it is a cold vacuum. We approach innovations in lyophilization equipment design and process the same way teams approach new spacecraft design. This time we’ve found a way to apply microwaves to get past some of the challenges the environment presents.”
Alexeenko is co-founder and co-director of LyoHUB, a university-industry center that brings together academic and industry researchers, representatives from government agencies, equipment manufacturers, and end-product users to improve freeze-drying technology to make food, pharmaceuticals and biotech products safer and more affordable.
The standard freeze-drying process is very expensive, but Alexeenko said the new technology could be much more cost-efficient, with the potential for an immediate impact on lives and the worldwide supply chain.
Merck and IMA Life North America Inc. have partnered with Purdue on the microwave project, which is funded by The National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL).
Merck is providing vaccine samples and leading development of benchmarks to compare the conventional and microwave lyophilization. IMA Life will lead integration of the new technology with the entire manufacturing process for sterile pharmaceuticals and vaccines.
“This microwave technology promises to not only provide uniformity to the drug product but also accelerate the freeze-drying process,” said Ernesto Renzi, president of sales and marketing at IMA Life North America.
In addition to Alexeenko, the research team at Purdue includes Eric Munson, the Dane O. Kildsig Chair and head of the Department of Industrial and Physical Pharmacy; Vivek Narsimhan, the Michael Ott Assistant Professor of Chemical Engineering in the Davidson School of Chemical Engineering; Dimitrios Peroulis, the Reilly Professor of Electrical and Computer Engineering and senior vice president for Purdue University Online; and Qi (Tony) Zhou, associate professor of industrial and physical pharmacy.
“This is a significant advancement of a technology that can have an immediate impact on lives and the U.S. supply chain,” said Karen Plaut, Purdue University’s executive vice president of research. “Centers like LyoHUB are a great example of how we draw upon Purdue’s deep research strengths and state-of-the-art facilities, such as Birck Nanotechnology Center, and leverage the expertise of industry and government to improve our world.”
Alexeenko’s startup, LyoWave, is working with Purdue Innovates Office of Technology Commercialization to bring this technology to the marketplace.
“This is yet another example of a Purdue innovation that can make an impact on the world,” said Purdue Innovates senior vice president Brooke Beier. “Purdue Innovates is focused on results: transforming research into intellectual property that can be licensed to startups and industries and, finally, products that can save lives.”
LyoHUB (http://www.lyohub.org), a university-industry center at Purdue University, is advancing the science and technology of lyophilization in order to lower costs and improve the availability of lyophilized products. Though time-consuming and inefficient in its current state, lyophilization is a critical manufacturing process for the pharmaceutical industry. It is used in about 25% of new injectable drugs, vaccines and biological products. The need for advancements in this area is magnified as COVID-19 lyophilized treatments, such as Gilead’s remdesivir, diagnostic reagents and other countermeasures are being developed and evaluated.
In addition to enhancing vaccines, biopharmaceuticals and diagnostics, lyophilization is used in food products. It is a $30 billion-dollar part of the food and pharmaceutical manufacturing industry.
LyoHUB was founded in 2014 with two member companies. Since then, it has grown to include 32 members. In 2017, it led the creation of the first lyophilization technology road map, which included more than 100 contributors from organizations across academic, industry and government institutions. LyoHUB also developed the first recognized consensus standard in lyophilization instrumentation issued by ASTM in 2021. The LyoHUB tech demo facility is located in the Birck Nanotechnology Center at Discovery Park District at Purdue.
About Purdue Innovates Office of Technology Commercialization
The Purdue Innovates Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university’s academic activities through commercializing, licensing and protecting Purdue intellectual property. In fiscal year 2022, the office reported 157 deals finalized with 237 technologies signed, 379 disclosures received and 169 issued U.S. patents. The office is managed by the Purdue Research Foundation, which received the 2019 Innovation and Economic Prosperity Universities Award for Place from the Association of Public and Land-grant Universities. In 2020, IPWatchdog Institute ranked Purdue third nationally in startup creation and in the top 20 for patents. The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University. Contact otcip@prf.org for more information.
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Media contact: Dustin Grove, dmgrove@prf.org
Source: Alina Alexeenko, alexeenk@purdue.edu
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